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PROCARBAZINE HCL

All products: general benefit

Other products in the same Health Canada class (L01X) — coverage varies; not interchangeable

  • Altretamine (Hexalen): general benefit
  • Hydroxyurea (Hydrea): general benefit
  • Mitotane (Lysodren): general benefit

Matulane · DIN 00012750 · 50mg · capsule

General benefitMarketed · checked 2026-09-02
StatusGeneral benefit
Write on scriptno code needed
Patient paysPatient pays: program not supplied; amount cannot be determined.
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
No interchangeable product listed in the Ontario extract
Matulane · DIN 00012750 Manufacturer: Leadiant Biosciences, Inc.; listing date 1996-10-01 Health Canada: Marketed since 2018-05-09 · brand MATULANE · ATC L01XB01 PROCARBAZINE · form Capsule · route Oral · ingredients PROCARBAZINE (PROCARBAZINE HYDROCHLORIDE) 50 MG · company Leadiant biosciences, inc · schedule Prescription
Check this DIN again · Health Canada product record

Matulane: Formulary list price $176.7388/unit (unit not stated in source; not the patient's cost)

Ministry pays: $176.7388 per source unit.

Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.

Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=938 · Verify on the e-Formulary ↗ (DIN 00012750)

Source record
DIN 00012750: Matulane Raw flags: sec3=Y Item: 100000021; group id 181; item number 0329; lccId None; manufacturer id LBI Source form: Cap; strength: 50mg Recorded listing: General benefit Source prices (unrounded): $176.7388; ministry $176.7388 Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=00012750 Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=938 Therapeutic Notes (formulary) Procarbazine inhibits monoamine oxidase. Avoid alcohol and foods with high tyramine content (e.g. aged cheese, red wine, yogurt, etc.)
Shortage status: resolved shortage (ended 2021-01-25); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada) Source: https://healthproductshortages.ca/search?term=00012750
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Other drugs in the same formulary class (10:00 ANTINEOPLASTIC AGENTS) and how they are covered

Matched class: 10:00 ANTINEOPLASTIC AGENTS

Drug-class inventory only. Lists recorded Ontario formulary products, not every Canadian medication; does not recommend treatment. Covered without a code on the Ontario formulary: ABIRATERONE ACETATE, ALTRETAMINE, ANASTROZOLE, BUSERELIN ACETATE, BUSULFAN, CAPECITABINE, CHLORAMBUCIL, CYPROTERONE ACETATE, DAUNORUBICIN, DEGARELIX ACETATE, ETOPOSIDE, EXEMESTANE, FLUOROURACIL & SALICYLIC ACID, FULVESTRANT, GOSERELIN ACETATE, HYDROXYUREA, IMATINIB MESYLATE, LETROZOLE, LEUPROLIDE ACETATE, MELPHALAN, MERCAPTOPURINE, MITOTANE, TEMOZOLOMIDE, THIOGUANINE, TRIPTORELIN PAMOATE Some products covered without a code (check the product listing): BICALUTAMIDE, CYCLOPHOSPHAMIDE, FLUTAMIDE, LOMUSTINE (CCNU), MEGESTROL ACETATE, METHOTREXATE, TAMOXIFEN CITRATE, VINCRISTINE SULFATE 10:00 ANTINEOPLASTIC AGENTS

ALTRETAMINE

· 1 products · General benefit · strengths: 50mg · Cap

HYDROXYUREA

· 3 products · General benefit · strengths: 500mg · Cap

MITOTANE

· 1 products · General benefit · strengths: 500mg · Tab

ABIRATERONE ACETATE

· 18 products · General benefit · strengths: 250mg, 500mg · Tab

ANASTROZOLE

· 17 products · General benefit · strengths: 1mg · Tab

BICALUTAMIDE

· 9 products · Listed, not a benefit (1), General benefit (8) · strengths: 50mg · Tab

BUSERELIN ACETATE

· 4 products · General benefit · strengths: 6.3mg, 9.45mg, 1mg/mL · Implant Kit, Inj Sol-5.5mL Pk, Nas Sp-10mL Pk

BUSULFAN

· 1 products · General benefit · strengths: 2mg · Tab

CAPECITABINE

· 15 products · General benefit · strengths: 150mg, 500mg · Tab

CHLORAMBUCIL

· 1 products · General benefit · strengths: 2mg · Tab

CYCLOPHOSPHAMIDE

· 3 products · General benefit (2), Listed, not a benefit (1) · strengths: 25mg, 50mg · Tab

CYPROTERONE ACETATE

· 4 products · General benefit · strengths: 50mg · Tab Source: formulary-ed43-front-matter.txt Part V; ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26; class 10:00 and 34 more
Full class listing Related classes: Same formulary class, not same indication: class membership alone does not establish equivalent uses.
What the Health Canada label says it is for
INDICATIONS AND CLINICAL USE Matulane (procarbazine hydrochloride) is indicated for use in combination with other anticancer agents for the treatment of Stage III and IV Hodgkin's disease. Matulane is used as part of the MOPP (mechlorethamine, vincristine, procarbazine, prednizone) regimen. Matulane has also been used successfully alone or in combination with other chemotherapeutic agents to produce regression in a variety of tumour types such as lymphomas and gliomas but data are not yet sufficient to justify specific recommendations. 3 https://pdf.hres.ca/dpd_pm/00040636.PDF PM date: August 9, 2017 Source product: MATULANE; DIN 00012750; fetched 2026-09-10 Product monograph posted by Health Canada; excerpt for lookup only.