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Lowest DBP recovery rule under medically necessary no-substitution claims: 6.2 Medically Necessary "No Substitution" Claims The Side Effect Reporting Form will not have to be renewed. However, the pharmacy must maintain a copy of the prescription that contains a direction that there be no substitution and the required Health Canada Side Effect Reporting Form (completed and signed by the prescriber). The prescriber must write “No Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will be reimbursed the DBP plus a mark-up and the lesser of the posted usual and customary fee or the ODB dispensing fee minus the applicable ODB co-payment amount. Where a completed Side Effect Reporting Form is not available at the pharmacy during an inspection, the difference between the cost of the higher-cost product and the lowest DBP listed for the interchangeable category will be recovered. (ontario.ca, Revision #17; 2026-08-03 ↗) 6.2 Medically Necessary "No Substitution" Claims The Ministry will provide reimbursement of a higher-cost interchangeable product in medically necessary circumstances where a patient has experienced a significant adverse reaction with two (2) lower-cost interchangeable drug products, where available. When a prescriber identifies a patient for which it is medically necessary that a higher cost interchangeable product be provided, the prescriber must: • Complete, sign and forward to the pharmacist a copy of the Health Canada side effect reporting form for each lower-cost interchangeable drug product trialed (Side Effect Reporting Form[s]); and • Write “No Substitution” or “No Sub” on a written prescription or indicate “No Substitution” to the pharmacist in the case of a verbal prescription. The prescriber should keep a copy of the completed form in the patient’s record for future use and reference. In the case of a written prescription, when the pharmacist or dispensing physician receives a prescription with the written notation “No Substitution” or “No Sub”, reimbursement will be provided for the higher-cost interchangeable product only if the prescription is accompanied by a completed Health Canada Side Effect Reporting Form for each of the lower-cost interchangeable drug products trialed. This form must be completely filled out noting the details of the adverse reaction and signed by the prescriber. In the case of a verbal prescription, the prescriber must satisfy the operator of the pharmacy or dispensing physician that a completed Health Canada Side Effect Reporting Form for each of the lower-cost interchangeable drug products trialed has been completed and signed by the prescriber. A written record of this verbal prescription and the completed Health Canada Side Effect Reporting Form must be received by the pharmacy prior to claim submission. Upon receipt, the pharmacist must: • Fax, submit online or mail the completed and signed form to Health Canada’s Canada Vigilance Program; and • Retain his or her copy of the completed and signed Side Effect Reporting Form. (ontario.ca, Revision #17; 2026-08-03 ↗)

Sandoz Venlafaxine XR · DIN 02310317 Manufacturer: Sandoz Canada Inc.; listing date 2008-08-28 Health Canada: Marketed since 2020-03-20 · brand SANDOZ VENLAFAXINE XR · ATC N06AX16 VENLAFAXINE · form Capsule (extended-release) · route Oral · ingredients VENLAFAXINE (VENLAFAXINE HYDROCHLORIDE) 37.5 MG · company Sandoz canada incorporated · schedule Prescription

DIN 02310317: Sandoz Venlafaxine XR Raw flags: sec3=Y Item: 281604087; group id 474; item number 1193; lccId None; manufacturer id SDZ Source form: ER Cap; strength: 37.5mg Recorded listing: General benefit Source prices (unrounded): $0.0913; ministry $0.0913 Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02310317 Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=79596

Interchangeable products

ACT Venlafaxine XR · DIN 02304317 · $0.0913 Apo-Venlafaxine XR · DIN 02331683 · $0.0913 Auro-Venlafaxine XR · DIN 02452839 · $0.0913 Effexor XR · DIN 02237279 · $0.0913 M-Venlafaxine XR · DIN 02471280 · $0.0913 Mint-Venlafaxine XR · DIN 02522977 · $0.0913 PMS-Venlafaxine XR · DIN 02278545 · $0.0913 PMSC-Venlafaxine XR · DIN 02521466 · $0.0913 Taro-Venlafaxine XR · DIN 02380072 · $0.0913 Teva-Venlafaxine XR · DIN 02275023 · $0.0913 Venlafaxine XR · DIN 02354713 · $0.0913 Venlafaxine XR · DIN 02385929 · $0.0913 Venlafaxine XR · DIN 02489678 · $0.0913 Venlafaxine XR · DIN 02516535 · $0.0913

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