Listed in the December 27, 2023 extract; not in the current extract (Aug 26, 2026): Eliquis (09857463), Apo-Apixaban (09858165), Ach-Apixaban (09858170), Jamp Apixaban (09858171), M-Apixaban (09858172), Mar-Apixaban (09858173), Nat-Apixaban (09858174), NRA-Apixaban (09858175), Sandoz Apixaban SDZ (09858176), Taro-Apixaban (09858177), Apixaban (09858180), Auro-Apixaban (09858239), Mint-Apixaban (09858249). Source: odb-formulary-ed43-extract-2023-12-27.xml; compared with odb-formulary-ed43-extract-2026-08-26.xml.
APIXABAN
All strengths: General benefit; same patient cost rules
Shared coverage and patient cost rules
StatusGeneral benefit
Patient paysPatient pays: program not supplied; amount cannot be determined.
Other products in the same Health Canada class (B01A, B01AF) — coverage varies; not interchangeable
- Edoxaban (Lixiana): general benefit
- Rivaroxaban (Xarelto): general benefit
- Dabigatran etexilate (Pradaxa): general benefit, Not a benefit
- Enoxaparin (Noromby): general benefit
- Warfarin (Coumadin): general benefit, Not a benefit
- Dalteparin (Fragmin): limited Use 186, 187, 188, 189
5 more in the class list below
Ach-Apixaban · DIN 02487713 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Ach-Apixaban · DIN 02487713
Manufacturer: Accord Healthcare Inc.; listing date 2022-11-30
Health Canada: Marketed since 2022-09-27 · brand ACH-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Accord healthcare inc · schedule Prescription
Check this DIN again · Health Canada product recordAch-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97786 · Verify on the e-Formulary ↗ (DIN 02487713)
Source record
DIN 02487713: Ach-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id ACH
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02487713
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97786
Interchangeable products
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: resolved shortage (ended 2025-11-21); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02487713
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Apixaban · DIN 02530708 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Apixaban · DIN 02530708
Manufacturer: Sivem Pharmaceuticals ULC; listing date 2022-12-21
Health Canada: Marketed since 2026-08-07 · brand APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Sivem pharmaceuticals ulc · schedule Prescription
Check this DIN again · Health Canada product recordApixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101986 · Verify on the e-Formulary ↗ (DIN 02530708)
Source record
DIN 02530708: Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id SIV
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02530708
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101986
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02530708
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Apixaban · DIN 02548879 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Apixaban · DIN 02548879
Manufacturer: Sanis Health Inc.; listing date 2024-12-30
Health Canada: Marketed since 2024-11-06 · brand APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Sanis health inc · schedule Prescription
Check this DIN again · Health Canada product recordApixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=103770 · Verify on the e-Formulary ↗ (DIN 02548879)
Source record
DIN 02548879: Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id SAI
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02548879
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=103770
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: shortage reported ended 2026-08-24 (report last updated 2026-08-24); confirm supply with the pharmacy; reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02548879
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Apo-Apixaban · DIN 02487381 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Apo-Apixaban · DIN 02487381
Manufacturer: Apotex Inc.; listing date 2022-08-31
Health Canada: Marketed since 2022-06-20 · brand APO-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Apotex inc · schedule Prescription
Check this DIN again · Health Canada product recordApo-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97756 · Verify on the e-Formulary ↗ (DIN 02487381)
Source record
DIN 02487381: Apo-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id APX
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02487381
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97756
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02487381
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Auro-Apixaban · DIN 02486806 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Auro-Apixaban · DIN 02486806
Manufacturer: Auro Pharma Inc.; listing date 2023-01-31
Health Canada: Marketed since 2022-11-28 · brand AURO-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Auro pharma inc · schedule Prescription
Check this DIN again · Health Canada product recordAuro-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97697 · Verify on the e-Formulary ↗ (DIN 02486806)
Source record
DIN 02486806: Auro-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id AUR
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02486806
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97697
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: resolved shortage (ended 2025-01-01); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02486806
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Bio-Apixaban · DIN 02527979 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Bio-Apixaban · DIN 02527979
Manufacturer: Biomed Pharma; listing date 2026-07-31
Health Canada: Marketed since 2022-09-21 · brand BIO-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Biomed pharma · schedule Prescription
Check this DIN again · Health Canada product recordBio-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101724 · Verify on the e-Formulary ↗ (DIN 02527979)
Source record
DIN 02527979: Bio-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id BMP
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02527979
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101724
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02527979
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Eliquis · DIN 02377233 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Savings card: RxHelp ONE lists ELIQUIS (read 2026-09-10) — brand-name savings card, free; cannot be combined with another card on the same claim.
(rxhelp.ca ↗)1 brand, same coverage
Eliquis · DIN 02377233
Manufacturer: Bristol Myers Squibb Canada Inc; listing date 2013-08-29
Health Canada: Marketed since 2012-02-01 · brand ELIQUIS · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Bristol-myers squibb canada · schedule Prescription
Check this DIN again · Health Canada product recordMinistry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=86287 · Verify on the e-Formulary ↗ (DIN 02377233)
Source record
DIN 02377233: Eliquis
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id BQU
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $1.6336; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02377233
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=86287
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02377233
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Jamp Apixaban · DIN 02528924 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Jamp Apixaban · DIN 02528924
Manufacturer: Jamp Pharma Corporation; listing date 2022-11-30
Health Canada: Marketed since 2022-09-20 · brand JAMP APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Jamp pharma corporation · schedule Prescription
Check this DIN again · Health Canada product recordJamp Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101810 · Verify on the e-Formulary ↗ (DIN 02528924)
Source record
DIN 02528924: Jamp Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id JPC
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02528924
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101810
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02528924
Shortage record checked 2026-09-13T08:10:21.292534+00:00
M-Apixaban · DIN 02529009 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
M-Apixaban · DIN 02529009
Manufacturer: Mantra Pharma Inc.; listing date 2022-11-30
Health Canada: Marketed since 2022-09-21 · brand M-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Mantra pharma inc · schedule Prescription
Check this DIN again · Health Canada product recordM-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101820 · Verify on the e-Formulary ↗ (DIN 02529009)
Source record
DIN 02529009: M-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id MAT
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02529009
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101820
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02529009
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Mar-Apixaban · DIN 02492369 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Mar-Apixaban · DIN 02492369
Manufacturer: Marcan Pharmaceuticals Inc.; listing date 2022-11-30
Health Canada: Marketed since 2022-09-21 · brand MAR-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Marcan pharmaceuticals inc · schedule Prescription
Check this DIN again · Health Canada product recordMar-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=98239 · Verify on the e-Formulary ↗ (DIN 02492369)
Source record
DIN 02492369: Mar-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id MAR
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02492369
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=98239
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02492369
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Mint-Apixaban · DIN 02495430 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Mint-Apixaban · DIN 02495430
Manufacturer: Mint Pharmaceuticals Inc.; listing date 2023-07-31
Health Canada: Marketed since 2023-04-17 · brand MINT-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Mint pharmaceuticals inc · schedule Prescription
Check this DIN again · Health Canada product recordMint-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=98535 · Verify on the e-Formulary ↗ (DIN 02495430)
Source record
DIN 02495430: Mint-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id MIN
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02495430
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=98535
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02495430
Shortage record checked 2026-09-13T08:10:21.292534+00:00
NRA-Apixaban Tablets · DIN 02546884 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
NRA-Apixaban Tablets · DIN 02546884
Manufacturer: Nora Pharma; listing date 2024-08-30
Health Canada: Marketed since 2024-04-22 · brand NRA-APIXABAN TABLETS · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Nora pharma inc · schedule Prescription
Check this DIN again · Health Canada product recordNRA-Apixaban Tablets: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=103555 · Verify on the e-Formulary ↗ (DIN 02546884)
Source record
DIN 02546884: NRA-Apixaban Tablets
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id NRA
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02546884
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=103555
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02546884
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Nat-Apixaban · DIN 02492814 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Nat-Apixaban · DIN 02492814
Manufacturer: Natco Pharma (Canada) Inc.; listing date 2022-11-30
Health Canada: Marketed since 2022-09-21 · brand NAT-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Natco pharma (canada) inc · schedule Prescription
Check this DIN again · Health Canada product recordNat-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=98281 · Verify on the e-Formulary ↗ (DIN 02492814)
Source record
DIN 02492814: Nat-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id NAT
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02492814
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=98281
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02492814
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Riva-Apixaban · DIN 02525518 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Riva-Apixaban · DIN 02525518
Manufacturer: Laboratoire Riva Inc.; listing date 2024-10-31
Health Canada: Marketed since 2026-02-26 · brand RIVA APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Laboratoire riva inc. · schedule Prescription
Check this DIN again · Health Canada product recordRiva-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101451 · Verify on the e-Formulary ↗ (DIN 02525518)
Source record
DIN 02525518: Riva-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id RIA
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02525518
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101451
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02525518
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Sandoz Apixaban SDZ · DIN 02489228 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Sandoz Apixaban SDZ · DIN 02489228
Manufacturer: Sandoz Canada Inc.; listing date 2022-11-30
Health Canada: Marketed since 2022-09-22 · brand SANDOZ APIXABAN SDZ · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Sandoz canada incorporated · schedule Prescription
Check this DIN again · Health Canada product recordSandoz Apixaban SDZ: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97930 · Verify on the e-Formulary ↗ (DIN 02489228)
Source record
DIN 02489228: Sandoz Apixaban SDZ
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id SDZ
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02489228
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97930
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: resolved shortage (ended 2026-02-02); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02489228
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Sandoz Apixaban Tablet · DIN 02487519 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Sandoz Apixaban Tablet · DIN 02487519
Manufacturer: Sandoz Canada Inc.; listing date 2026-06-30
Health Canada: Marketed since 2026-05-11 · brand SANDOZ APIXABAN TABLET · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Sandoz canada incorporated · schedule Prescription
Check this DIN again · Health Canada product recordSandoz Apixaban Tablet: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97767 · Verify on the e-Formulary ↗ (DIN 02487519)
Source record
DIN 02487519: Sandoz Apixaban Tablet
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id SDZ
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02487519
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97767
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02487519
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Taro-Apixaban · DIN 02510464 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Taro-Apixaban · DIN 02510464
Manufacturer: Taro Pharmaceuticals Inc.; listing date 2022-11-30
Health Canada: Marketed since 2022-09-21 · brand TARO-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Sun pharma canada inc · schedule Prescription
Check this DIN again · Health Canada product recordTaro-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=99968 · Verify on the e-Formulary ↗ (DIN 02510464)
Source record
DIN 02510464: Taro-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id TAR
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02510464
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=99968
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Teva-Apixaban · DIN 02484994 · $0.4084
Shortage status: resolved shortage (ended 2025-04-10); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02510464
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Teva-Apixaban · DIN 02484994 · 2.5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Teva-Apixaban · DIN 02484994
Manufacturer: Teva Canada Limited; listing date 2024-01-31
Health Canada: Marketed since 2023-09-22 · brand TEVA-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 2.5 MG · company Teva canada limited · schedule Prescription
Check this DIN again · Health Canada product recordTeva-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97524 · Verify on the e-Formulary ↗ (DIN 02484994)
Source record
DIN 02484994: Teva-Apixaban
Raw flags: sec3=Y
Item: 201200089; group id 251; item number 0443; lccId None; manufacturer id TEV
Source form: Tab; strength: 2.5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02484994
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97524
Interchangeable products
Ach-Apixaban · DIN 02487713 · $0.4084
Apixaban · DIN 02530708 · $0.4084
Apixaban · DIN 02548879 · $0.4084
Apo-Apixaban · DIN 02487381 · $0.4084
Auro-Apixaban · DIN 02486806 · $0.4084
Bio-Apixaban · DIN 02527979 · $0.4084
Eliquis · DIN 02377233 · $0.4084
Jamp Apixaban · DIN 02528924 · $0.4084
M-Apixaban · DIN 02529009 · $0.4084
Mar-Apixaban · DIN 02492369 · $0.4084
Mint-Apixaban · DIN 02495430 · $0.4084
NRA-Apixaban · DIN 02526050 · $0.4084
NRA-Apixaban Tablets · DIN 02546884 · $0.4084
Nat-Apixaban · DIN 02492814 · $0.4084
Riva-Apixaban · DIN 02525518 · $0.4084
Sandoz Apixaban SDZ · DIN 02489228 · $0.4084
Sandoz Apixaban Tablet · DIN 02487519 · $0.4084
Taro-Apixaban · DIN 02510464 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02484994
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Ach-Apixaban · DIN 02487721 · 5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Ach-Apixaban · DIN 02487721
Manufacturer: Accord Healthcare Inc.; listing date 2022-11-30
Health Canada: Marketed since 2022-09-27 · brand ACH-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 5 MG · company Accord healthcare inc · schedule Prescription
Check this DIN again · Health Canada product recordAch-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97787 · Verify on the e-Formulary ↗ (DIN 02487721)
Source record
DIN 02487721: Ach-Apixaban
Raw flags: sec3=Y
Item: 201200090; group id 251; item number 0444; lccId None; manufacturer id ACH
Source form: Tab; strength: 5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02487721
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97787
Interchangeable products
Apixaban · DIN 02530716 · $0.4084
Apixaban · DIN 02548887 · $0.4084
Apo-Apixaban · DIN 02487403 · $0.4084
Auro-Apixaban · DIN 02486814 · $0.4084
Bio-Apixaban · DIN 02527987 · $0.4084
Eliquis · DIN 02397714 · $0.4084
Jamp Apixaban · DIN 02528932 · $0.4084
M-Apixaban · DIN 02529017 · $0.4084
Mar-Apixaban · DIN 02492377 · $0.4084
Mint-Apixaban · DIN 02495449 · $0.4084
NRA-Apixaban · DIN 02526069 · $0.4084
NRA-Apixaban Tablets · DIN 02546892 · $0.4084
Nat-Apixaban · DIN 02492822 · $0.4084
Riva-Apixaban · DIN 02525526 · $0.4084
Sandoz Apixaban SDZ · DIN 02489236 · $0.4084
Sandoz Apixaban Tablet · DIN 02487527 · $0.4084
Taro-Apixaban · DIN 02510472 · $0.4084
Teva-Apixaban · DIN 02485001 · $0.4084
Shortage status: resolved shortage (ended 2025-11-27); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02487721
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Apixaban · DIN 02530716 · 5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Apixaban · DIN 02530716
Manufacturer: Sivem Pharmaceuticals ULC; listing date 2022-12-21
Health Canada: Marketed since 2026-08-07 · brand APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 5 MG · company Sivem pharmaceuticals ulc · schedule Prescription
Check this DIN again · Health Canada product recordApixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101987 · Verify on the e-Formulary ↗ (DIN 02530716)
Source record
DIN 02530716: Apixaban
Raw flags: sec3=Y
Item: 201200090; group id 251; item number 0444; lccId None; manufacturer id SIV
Source form: Tab; strength: 5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02530716
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101987
Interchangeable products
Ach-Apixaban · DIN 02487721 · $0.4084
Apixaban · DIN 02548887 · $0.4084
Apo-Apixaban · DIN 02487403 · $0.4084
Auro-Apixaban · DIN 02486814 · $0.4084
Bio-Apixaban · DIN 02527987 · $0.4084
Eliquis · DIN 02397714 · $0.4084
Jamp Apixaban · DIN 02528932 · $0.4084
M-Apixaban · DIN 02529017 · $0.4084
Mar-Apixaban · DIN 02492377 · $0.4084
Mint-Apixaban · DIN 02495449 · $0.4084
NRA-Apixaban · DIN 02526069 · $0.4084
NRA-Apixaban Tablets · DIN 02546892 · $0.4084
Nat-Apixaban · DIN 02492822 · $0.4084
Riva-Apixaban · DIN 02525526 · $0.4084
Sandoz Apixaban SDZ · DIN 02489236 · $0.4084
Sandoz Apixaban Tablet · DIN 02487527 · $0.4084
Taro-Apixaban · DIN 02510472 · $0.4084
Teva-Apixaban · DIN 02485001 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02530716
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Apixaban · DIN 02548887 · 5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Apixaban · DIN 02548887
Manufacturer: Sanis Health Inc.; listing date 2024-12-30
Health Canada: Marketed since 2024-11-06 · brand APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 5 MG · company Sanis health inc · schedule Prescription
Check this DIN again · Health Canada product recordApixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=103771 · Verify on the e-Formulary ↗ (DIN 02548887)
Source record
DIN 02548887: Apixaban
Raw flags: sec3=Y
Item: 201200090; group id 251; item number 0444; lccId None; manufacturer id SAI
Source form: Tab; strength: 5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02548887
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=103771
Interchangeable products
Ach-Apixaban · DIN 02487721 · $0.4084
Apixaban · DIN 02530716 · $0.4084
Apo-Apixaban · DIN 02487403 · $0.4084
Auro-Apixaban · DIN 02486814 · $0.4084
Bio-Apixaban · DIN 02527987 · $0.4084
Eliquis · DIN 02397714 · $0.4084
Jamp Apixaban · DIN 02528932 · $0.4084
M-Apixaban · DIN 02529017 · $0.4084
Mar-Apixaban · DIN 02492377 · $0.4084
Mint-Apixaban · DIN 02495449 · $0.4084
NRA-Apixaban · DIN 02526069 · $0.4084
NRA-Apixaban Tablets · DIN 02546892 · $0.4084
Nat-Apixaban · DIN 02492822 · $0.4084
Riva-Apixaban · DIN 02525526 · $0.4084
Sandoz Apixaban SDZ · DIN 02489236 · $0.4084
Sandoz Apixaban Tablet · DIN 02487527 · $0.4084
Taro-Apixaban · DIN 02510472 · $0.4084
Teva-Apixaban · DIN 02485001 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02548887
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Apo-Apixaban · DIN 02487403 · 5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Apo-Apixaban · DIN 02487403
Manufacturer: Apotex Inc.; listing date 2022-08-31
Health Canada: Marketed since 2022-06-20 · brand APO-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 5 MG · company Apotex inc · schedule Prescription
Check this DIN again · Health Canada product recordApo-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97757 · Verify on the e-Formulary ↗ (DIN 02487403)
Source record
DIN 02487403: Apo-Apixaban
Raw flags: sec3=Y
Item: 201200090; group id 251; item number 0444; lccId None; manufacturer id APX
Source form: Tab; strength: 5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02487403
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97757
Interchangeable products
Ach-Apixaban · DIN 02487721 · $0.4084
Apixaban · DIN 02530716 · $0.4084
Apixaban · DIN 02548887 · $0.4084
Auro-Apixaban · DIN 02486814 · $0.4084
Bio-Apixaban · DIN 02527987 · $0.4084
Eliquis · DIN 02397714 · $0.4084
Jamp Apixaban · DIN 02528932 · $0.4084
M-Apixaban · DIN 02529017 · $0.4084
Mar-Apixaban · DIN 02492377 · $0.4084
Mint-Apixaban · DIN 02495449 · $0.4084
NRA-Apixaban · DIN 02526069 · $0.4084
NRA-Apixaban Tablets · DIN 02546892 · $0.4084
Nat-Apixaban · DIN 02492822 · $0.4084
Riva-Apixaban · DIN 02525526 · $0.4084
Sandoz Apixaban SDZ · DIN 02489236 · $0.4084
Sandoz Apixaban Tablet · DIN 02487527 · $0.4084
Taro-Apixaban · DIN 02510472 · $0.4084
Teva-Apixaban · DIN 02485001 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02487403
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Auro-Apixaban · DIN 02486814 · 5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Auro-Apixaban · DIN 02486814
Manufacturer: Auro Pharma Inc.; listing date 2023-01-31
Health Canada: Marketed since 2022-11-28 · brand AURO-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 5 MG · company Auro pharma inc · schedule Prescription
Check this DIN again · Health Canada product recordAuro-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97698 · Verify on the e-Formulary ↗ (DIN 02486814)
Source record
DIN 02486814: Auro-Apixaban
Raw flags: sec3=Y
Item: 201200090; group id 251; item number 0444; lccId None; manufacturer id AUR
Source form: Tab; strength: 5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02486814
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=97698
Interchangeable products
Ach-Apixaban · DIN 02487721 · $0.4084
Apixaban · DIN 02530716 · $0.4084
Apixaban · DIN 02548887 · $0.4084
Apo-Apixaban · DIN 02487403 · $0.4084
Bio-Apixaban · DIN 02527987 · $0.4084
Eliquis · DIN 02397714 · $0.4084
Jamp Apixaban · DIN 02528932 · $0.4084
M-Apixaban · DIN 02529017 · $0.4084
Mar-Apixaban · DIN 02492377 · $0.4084
Mint-Apixaban · DIN 02495449 · $0.4084
NRA-Apixaban · DIN 02526069 · $0.4084
NRA-Apixaban Tablets · DIN 02546892 · $0.4084
Nat-Apixaban · DIN 02492822 · $0.4084
Riva-Apixaban · DIN 02525526 · $0.4084
Sandoz Apixaban SDZ · DIN 02489236 · $0.4084
Sandoz Apixaban Tablet · DIN 02487527 · $0.4084
Taro-Apixaban · DIN 02510472 · $0.4084
Teva-Apixaban · DIN 02485001 · $0.4084
Shortage status: resolved shortage (ended 2025-01-01); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02486814
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Bio-Apixaban · DIN 02527987 · 5mg · tablet
General benefitMarketed · checked 2026-09-02
Write on scriptno code needed
Private plan unknown: ask. If yes, check its coverage and payer coordination; if no, see the public routes below.
Brand vs generic price
Lowest DBP recovery rule under medically necessary no-substitution claims:
6.2 Medically Necessary "No Substitution" Claims
The Side Effect Reporting Form will not have to be renewed. However, the
pharmacy must maintain a copy of the prescription that contains a direction that
there be no substitution and the required Health Canada Side Effect Reporting Form
(completed and signed by the prescriber). The prescriber must write “No
Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and
indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will
be reimbursed the DBP plus a mark-up and the lesser of the posted usual and
customary fee or the ODB dispensing fee minus the applicable ODB co-payment
amount. Where a completed Side Effect Reporting Form is not available at the
pharmacy during an inspection, the difference between the cost of the higher-cost
product and the lowest DBP listed for the interchangeable category will be
recovered.
(ontario.ca, Revision #17; 2026-08-03 ↗)
6.2 Medically Necessary "No Substitution" Claims
The Ministry will provide reimbursement of a higher-cost interchangeable product in
medically necessary circumstances where a patient has experienced a significant
adverse reaction with two (2) lower-cost interchangeable drug products, where
available. When a prescriber identifies a patient for which it is medically necessary
that a higher cost interchangeable product be provided, the prescriber must:
• Complete, sign and forward to the pharmacist a copy of the Health Canada
side effect reporting form for each lower-cost interchangeable drug product
trialed (Side Effect Reporting Form[s]); and
• Write “No Substitution” or “No Sub” on a written prescription or indicate “No
Substitution” to the pharmacist in the case of a verbal prescription.
The prescriber should keep a copy of the completed form in the patient’s record for
future use and reference.
In the case of a written prescription, when the pharmacist or dispensing physician
receives a prescription with the written notation “No Substitution” or “No Sub”,
reimbursement will be provided for the higher-cost interchangeable product only if
the prescription is accompanied by a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed.
This form must be completely filled out noting the details of the adverse reaction
and signed by the prescriber.
In the case of a verbal prescription, the prescriber must satisfy the operator of the
pharmacy or dispensing physician that a completed Health Canada Side Effect
Reporting Form for each of the lower-cost interchangeable drug products trialed
has been completed and signed by the prescriber. A written record of this verbal
prescription and the completed Health Canada Side Effect Reporting Form must be
received by the pharmacy prior to claim submission.
Upon receipt, the pharmacist must:
• Fax, submit online or mail the completed and signed form to Health Canada’s
Canada Vigilance Program; and
• Retain his or her copy of the completed and signed Side Effect Reporting
Form.
(ontario.ca, Revision #17; 2026-08-03 ↗)1 brand, same coverage
Bio-Apixaban · DIN 02527987
Manufacturer: Biomed Pharma; listing date 2026-07-31
Health Canada: Marketed since 2022-09-21 · brand BIO-APIXABAN · ATC B01AF02 APIXABAN · form Tablet · route Oral · ingredients APIXABAN 5 MG · company Biomed pharma · schedule Prescription
Check this DIN again · Health Canada product recordBio-Apixaban: Formulary list price $0.4084/unit (unit not stated in source; not the patient's cost)
Ministry pays: $0.4084 per source unit.
Source explanation: The formulary price is what ODB pays; the cash price at the counter is set by the pharmacy.
Formulary data: Ontario extract of Aug 26, 2026 · Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101725 · Verify on the e-Formulary ↗ (DIN 02527987)
Source record
DIN 02527987: Bio-Apixaban
Raw flags: sec3=Y
Item: 201200090; group id 251; item number 0444; lccId None; manufacturer id BMP
Source form: Tab; strength: 5mg
Recorded listing: General benefit
Source prices (unrounded): $0.4084; ministry $0.4084
Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02527987
Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=101725
Interchangeable products
Ach-Apixaban · DIN 02487721 · $0.4084
Apixaban · DIN 02530716 · $0.4084
Apixaban · DIN 02548887 · $0.4084
Apo-Apixaban · DIN 02487403 · $0.4084
Auro-Apixaban · DIN 02486814 · $0.4084
Eliquis · DIN 02397714 · $0.4084
Jamp Apixaban · DIN 02528932 · $0.4084
M-Apixaban · DIN 02529017 · $0.4084
Mar-Apixaban · DIN 02492377 · $0.4084
Mint-Apixaban · DIN 02495449 · $0.4084
NRA-Apixaban · DIN 02526069 · $0.4084
NRA-Apixaban Tablets · DIN 02546892 · $0.4084
Nat-Apixaban · DIN 02492822 · $0.4084
Riva-Apixaban · DIN 02525526 · $0.4084
Sandoz Apixaban SDZ · DIN 02489236 · $0.4084
Sandoz Apixaban Tablet · DIN 02487527 · $0.4084
Taro-Apixaban · DIN 02510472 · $0.4084
Teva-Apixaban · DIN 02485001 · $0.4084
Shortage status: no shortage or discontinuation reported (checked 2026-09-13T08:10:21.292534+00:00); reports as of 2026-09-13T08:10:21.292534+00:00 (Health Product Shortages Canada)
Source: https://healthproductshortages.ca/search?term=02527987
Shortage record checked 2026-09-13T08:10:21.292534+00:00
Other drugs in the same formulary class (20:12 Coagulants and Anti-Coagulants) and how they are covered
Matched class: 20:12 Coagulants and Anti-Coagulants
Drug-class inventory only. Lists recorded Ontario formulary products, not every Canadian medication; does not recommend treatment.
Covered without a code on the Ontario formulary: ENOXAPARIN, RIVAROXABAN
Some products covered without a code (check the product listing): DABIGATRAN ETEXILATE, EDOXABAN, WARFARIN
20:12 Coagulants and Anti-Coagulants
· 48 products · General benefit · strengths: 2.5mg, 10mg, 15mg, 20mg · Tab
· 6 products · Off-Formulary Interchangeable, not an ODB benefit (2), General benefit (4) · strengths: 75mg, 110mg, 150mg · Cap
· 37 products · General benefit · strengths: 20mg/0.2mL, 30mg/0.3mL, 40mg/0.4mL, 60mg/0.6mL, 80mg/0.8mL, 120mg/0.8mL, 100mg/mL, 150mg/mL, 300mg/3mL · Inj Sol-0.2mL Pref Syr (Preservative-Free), Inj Sol-0.3mL Pref Syr (Preservative-Free), Inj Sol-0.4mL Pref Syr (Preservative-Free), Inj Sol-0.6mL Pref Syr (Preservative-Free), Inj Sol-0.8mL Pref Syr (Preservative-Free), Inj Sol-1mL Pref Syr (Preservative-Free), Inj Sol-3mL Vial Pk (With Preservative)
· 23 products · Listed, not a benefit (8), General benefit (14), Off-Formulary Interchangeable, not an ODB benefit (1) · strengths: 1mg, 2mg, 2.5mg, 3mg, 4mg, 5mg, 6mg, 10mg · Tab
· 10 products ·
Limited Use, codes 186, 187, 188, 189 · strengths: 3500IU/0.28mL, 7500IU/0.3mL, 2500IU/0.2mL, 5000IU/0.2mL, 10000IU/0.4mL, 12500IU/0.5mL, 15000IU/0.6mL, 18000IU/0.72mL, 16500IU/0.66mL, 25000IU/mL · Inj Pref Syr, Inj Pref Syr-0.66mL Pk, Multidose 3.8mL Pk
· 4 products ·
Limited Use, codes 378 (2), Off-Formulary Interchangeable, not an ODB benefit (2) · strengths: 2.5mg/0.5mL, 7.5mg/0.6mL · Inj Sol-Pref Syr 0.5mL Pk (Preservative Free), Inj Sol-Pref Syr 0.6mL Pk (Preservative Free)
· 7 products ·
Limited Use, codes 186, 187, 188, 189 · strengths: 9500IU/mL, 19000IU/mL · Pref Syr-0.3mL Pk, Pref Syr-0.4mL Pk, Pref Syr-0.6mL Pk, Pref Syr-0.8mL Pk, Pref Syr-1.0mL Pk
· 10 products · Off-Formulary Interchangeable, not an ODB benefit (5),
Limited Use, codes 441 (5) · strengths: 60mg, 90mg · Tab
· 11 products ·
Limited Use, codes 186, 187, 188, 189, 323 · strengths: 2500IU/0.25mL, 8000IU/0.4mL, 12000IU/0.6mL, 16000IU/0.8mL, 3500IU/0.35mL, 4500IU/0.45mL, 10000IU/0.5mL, 14000IU/0.7mL, 18000IU/0.9mL, 10000IU/mL, 20000IU/mL · Inj Pref Syr, Inj-2mL Pk
· 6 products · Off-Formulary Interchangeable, not an ODB benefit · strengths: 0.75mg/mL, 2mg/mL · 100mL Vial Pk, 10mL Vial Pk
Source: formulary-ed43-front-matter.txt Part V; ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26; class 20:12
20:12:04 Direct Factor Xa Inhibitors
· 11 products · General benefit; DIN status E (meaning unconfirmed); confirm discontinuation/availability with Health Canada (3), General benefit (8) · strengths: 15mg, 30mg, 60mg · Tab
Source: formulary-ed43-front-matter.txt Part V; ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26; class 20:12:04
20:12:16 Hemostatics
· 5 products · Off-Formulary Interchangeable, not an ODB benefit · strengths: 500mg · Tab
Source: formulary-ed43-front-matter.txt Part V; ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26; class 20:12:16
Full class listing
Related classes: 20:04 Antianemia Drugs, 20:16 Hematopoietic Agents, 20:24 Hemorrheologic Agents
Same formulary class, not same indication: class membership alone does not establish equivalent uses.