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Lowest DBP recovery rule under medically necessary no-substitution claims: 6.2 Medically Necessary "No Substitution" Claims The Side Effect Reporting Form will not have to be renewed. However, the pharmacy must maintain a copy of the prescription that contains a direction that there be no substitution and the required Health Canada Side Effect Reporting Form (completed and signed by the prescriber). The prescriber must write “No Substitution” or “No Sub” on renewal or subsequent new written prescriptions, and indicate “No Substitution” on subsequent new oral prescriptions. The dispenser will be reimbursed the DBP plus a mark-up and the lesser of the posted usual and customary fee or the ODB dispensing fee minus the applicable ODB co-payment amount. Where a completed Side Effect Reporting Form is not available at the pharmacy during an inspection, the difference between the cost of the higher-cost product and the lowest DBP listed for the interchangeable category will be recovered. (ontario.ca, Revision #17; 2026-08-03 ↗) 6.2 Medically Necessary "No Substitution" Claims The Ministry will provide reimbursement of a higher-cost interchangeable product in medically necessary circumstances where a patient has experienced a significant adverse reaction with two (2) lower-cost interchangeable drug products, where available. When a prescriber identifies a patient for which it is medically necessary that a higher cost interchangeable product be provided, the prescriber must: • Complete, sign and forward to the pharmacist a copy of the Health Canada side effect reporting form for each lower-cost interchangeable drug product trialed (Side Effect Reporting Form[s]); and • Write “No Substitution” or “No Sub” on a written prescription or indicate “No Substitution” to the pharmacist in the case of a verbal prescription. The prescriber should keep a copy of the completed form in the patient’s record for future use and reference. In the case of a written prescription, when the pharmacist or dispensing physician receives a prescription with the written notation “No Substitution” or “No Sub”, reimbursement will be provided for the higher-cost interchangeable product only if the prescription is accompanied by a completed Health Canada Side Effect Reporting Form for each of the lower-cost interchangeable drug products trialed. This form must be completely filled out noting the details of the adverse reaction and signed by the prescriber. In the case of a verbal prescription, the prescriber must satisfy the operator of the pharmacy or dispensing physician that a completed Health Canada Side Effect Reporting Form for each of the lower-cost interchangeable drug products trialed has been completed and signed by the prescriber. A written record of this verbal prescription and the completed Health Canada Side Effect Reporting Form must be received by the pharmacy prior to claim submission. Upon receipt, the pharmacist must: • Fax, submit online or mail the completed and signed form to Health Canada’s Canada Vigilance Program; and • Retain his or her copy of the completed and signed Side Effect Reporting Form. (ontario.ca, Revision #17; 2026-08-03 ↗)

Losartan HCT · DIN 02388960 Manufacturer: Sivem Pharmaceuticals ULC; listing date 2020-09-30 Health Canada: Marketed since 2025-10-07 · brand LOSARTAN HCT · ATC C09DA01 LOSARTAN AND DIURETICS · form Tablet · route Oral · ingredients LOSARTAN POTASSIUM 50 MG, HYDROCHLOROTHIAZIDE 12.5 MG · company Sivem pharmaceuticals ulc · schedule Prescription

DIN 02388960: Losartan HCT Raw flags: chronicUseMed=Y, sec3=Y Item: 240800226; group id 336; item number 0761; lccId None; manufacturer id SIV Source form: Tab; strength: 50mg & 12.5mg Recorded listing: General benefit; chronic-use medication (100-day supply rule, dispensing-fee limit) Source prices (unrounded): $0.3147; ministry $0.3147 Source: ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26 DIN=02388960 Health Canada DPD extract of Sep 2, 2026 (Open Government Licence – Canada) · https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=87449

Interchangeable products

Apo-Losartan/HCTZ · DIN 02371235 · $0.3147 Auro-Losartan HCT · DIN 02423642 · $0.3147 Co Losartan/HCT · DIN 02388251 · $0.3147 Hyzaar · DIN 02230047 · $0.3147 Jamp-Losartan HCTZ · DIN 02408244 · $0.3147 Losartan/HCTZ · DIN 02427648 · $0.3147 Mint-Losartan/HCTZ · DIN 02389657 · $0.3147 PMS-Losartan-HCTZ · DIN 02392224 · $0.3147 Sandoz Losartan HCT · DIN 02313375 · $0.3147 Septa-Losartan HCTZ · DIN 02428539 · $0.3147 Teva-Losartan/HCTZ · DIN 02358263 · $0.3147

Shortage status: not checked (no credentials)