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Matched class: 68:20:10 Insulins (Rapid Acting)

Drug-class inventory only. Lists recorded Ontario formulary products, not every Canadian medication; does not recommend treatment. Covered without a code on the Ontario formulary: INSULIN (ZINC CRYSTALLINE) HUMAN BIOSYNTHETIC (RDNA ORIGIN), INSULIN GLULISINE (DNA ORIGIN), INSULIN HUMAN BIOSYNTHETIC, INSULIN INJECTION, HUMAN BIOSYNTHETIC Some products covered without a code (check the product listing): INSULIN ASPART 68:20:10 Insulins (Rapid Acting)

INSULIN (ZINC CRYSTALLINE) HUMAN BIOSYNTHETIC (RDNA ORIGIN)

· 2 products · General benefit · strengths: 1000U/10mL, 100U/mL · Inj Sol-10mL Pk, Inj Sol-5x3mL Pk

INSULIN ASPART

· 5 products · Limited Use, codes 646 (1), General benefit (4) · strengths: 100U/mL · Inj Sol-10mL Pk, Inj Sol-10mL Vial Pk, Inj Sol-5x3mL Cart Pk, Inj Sol-5X3mL Pref Pen Pk, Inj Sol-5x3mL SoloSTAR Pref Pen Pk

INSULIN GLULISINE (DNA ORIGIN)

· 3 products · General benefit · strengths: 100U/mL · Inj 5x3mL Cart ClickStar Pen, Inj Sol-10mL Vial, Inj Sol-5x3mL SoloSTAR Pref Pen

INSULIN HUMAN BIOSYNTHETIC

· 2 products · General benefit · strengths: 1000U/10mL, 100U/mL · Inj Sol-10mL Pk, Inj Sol-5x3mL Pk

INSULIN INJECTION, HUMAN BIOSYNTHETIC

· 1 products · General benefit · strengths: 500U/mL · Inj Sol-Pref Pen 2x3mL Pk Source: formulary-ed43-front-matter.txt Part V; ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26; class 68:20:10

Matched class: 68:20:16 Insulins (Pre-Mixed)

Drug-class inventory only. Lists recorded Ontario formulary products, not every Canadian medication; does not recommend treatment. Covered without a code on the Ontario formulary: INSULIN (30% NEUTRAL & 70% ISOPHANE) HUMAN BIOSYNTHETIC, INSULIN ASPART 30% & INSULIN ASPART PROTAMINE 70%, INSULIN HUMAN BIOSYNTHETIC 30% & ISOPHANE 70% 68:20:16 Insulins (Pre-Mixed)

INSULIN (30% NEUTRAL & 70% ISOPHANE) HUMAN BIOSYNTHETIC

· 2 products · General benefit · strengths: 1000U/10mL, 100U/mL · Inj Susp-10mL Pk, Inj Susp-5x3mL Pk

INSULIN ASPART 30% & INSULIN ASPART PROTAMINE 70%

· 1 products · General benefit · strengths: 100U/mL · Inj Susp-5x3mL Pk

INSULIN HUMAN BIOSYNTHETIC 30% & ISOPHANE 70%

· 2 products · General benefit · strengths: 1000U/10mL, 100U/mL · Inj Susp-10mL Pk, Inj Susp-5x3mL Pk Source: formulary-ed43-front-matter.txt Part V; ODB odb-formulary-ed43-extract-2026-08-26.xml extract_date=2026-08-26; class 68:20:16

From Health Canada product monographs; label wording only, not a treatment recommendation. Matching is lexical and uses one held product label per generic; formulations and qualifying criteria may differ. Covered without a code on the Ontario formulary: INSULIN (30% NEUTRAL & 70% ISOPHANE) HUMAN BIOSYNTHETIC, INSULIN (ISOPHANE) HUMAN BIOSYNTHETIC, INSULIN ASPART 30% & INSULIN ASPART PROTAMINE 70%, INSULIN HUMAN BIOSYNTHETIC INSULIN (30% NEUTRAL & 70% ISOPHANE) HUMAN BIOSYNTHETIC · General benefit 1 INDICATIONS Novolin®ge (Insulin, Human Biosynthetic) is indicated for: • The treatment of patients with diabetes mellitus who require insulin for the control of hyperglycemia. PM: https://pdf.hres.ca/dpd_pm/00077108.PDF; date JAN 07, 2011; DIN 02024217; fetched 2026-09-10 Product monograph INSULIN (ISOPHANE) HUMAN BIOSYNTHETIC · General benefit 1 INDICATIONS Novolin®ge (Insulin, Human Biosynthetic) is indicated for: • The treatment of patients with diabetes mellitus who require insulin for the control of hyperglycemia. PM: https://pdf.hres.ca/dpd_pm/00077108.PDF; date JAN 07, 2011; DIN 02024225; fetched 2026-09-10 Product monograph INSULIN ASPART · Limited Use, codes 646 (1), General benefit (4) 1 Indications NOVORAPID® (insulin aspart) is indicated for: • The treatment of patients with diabetes mellitus who require insulin for the control of hyperglycemia. PM: https://pdf.hres.ca/dpd_pm/00084670.PDF; date 2026-05-12; DIN 02245397; fetched 2026-09-10 Product monograph • The treatment of patients with diabetes mellitus who require insulin for the control of hyperglycemia. NOVORAPID® should normally be used in regimens together with an intermediate or long-acting insulin. NOVORAPID® (10 mL vials) may also be used for continuous subcutaneous insulin infusion (CSII) in pump systems which are licensed in Canada for insulin infusion. PM: https://pdf.hres.ca/dpd_pm/00084670.PDF; date 2026-05-12; DIN 02245397; fetched 2026-09-10 Product monograph INSULIN ASPART 30% & INSULIN ASPART PROTAMINE 70% · General benefit  The treatment of adult patients with diabetes mellitus who require insulin for the control of hyperglycemia. PM: https://pdf.hres.ca/dpd_pm/00062479.PDF; date JUL 11, 2017; DIN 02265435; fetched 2026-09-10 Product monograph INSULIN HUMAN BIOSYNTHETIC · General benefit 1 INDICATIONS Novolin®ge (Insulin, Human Biosynthetic) is indicated for: • The treatment of patients with diabetes mellitus who require insulin for the control of hyperglycemia. PM: https://pdf.hres.ca/dpd_pm/00077108.PDF; date JAN 07, 2011; DIN 02024233; fetched 2026-09-10 Product monograph Coverage source: ON formulary extract 2026-08-26

INDICATIONS AND CLINICAL USE HUMALOG (insulin lispro injection), HUMALOG MIX25 (25% insulin lispro injection, 75% insulin lispro protamine suspension), and HUMALOG MIX50 (50% insulin lispro injection, 50% insulin lispro protamine suspension) are indicated for the treatment of patients with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. HUMALOG insulins are also indicated for the initial stabilization of diabetes mellitus. HUMALOG (insulin lispro injection) is a fast-acting insulin analogue and is for use in conjunction with a longer HUMALOG, HUMALOG 200 units/mL KwikPen, HUMALOG MIX25, HUMALOG MIX50 Page 3 of 63 acting insulin, such as HUMULIN N (insulin isophane (rDNA origin) NPH), except when used in a subcutaneous insulin infusion pump. HUMALOG 200 units/mL KwikPen (insulin lispro injection) is reserved for the treatment of patients with diabetes requiring daily doses of more than 20 units of fast-acting insulin. https://pdf.hres.ca/dpd_pm/00063278.PDF PM date: April 12, 2021 Source product: HUMALOG; DIN 02229704; fetched 2026-09-10 Product monograph posted by Health Canada; excerpt for lookup only.

INDICATIONS AND CLINICAL USE HUMALOG (insulin lispro injection), HUMALOG MIX25 (25% insulin lispro injection, 75% insulin lispro protamine suspension), and HUMALOG MIX50 (50% insulin lispro injection, 50% insulin lispro protamine suspension) are indicated for the treatment of patients with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. HUMALOG insulins are also indicated for the initial stabilization of diabetes mellitus. HUMALOG (insulin lispro injection) is a fast-acting insulin analogue and is for use in conjunction with a longer HUMALOG, HUMALOG 200 units/mL KwikPen, HUMALOG MIX25, HUMALOG MIX50 Page 3 of 63 acting insulin, such as HUMULIN N (insulin isophane (rDNA origin) NPH), except when used in a subcutaneous insulin infusion pump. HUMALOG 200 units/mL KwikPen (insulin lispro injection) is reserved for the treatment of patients with diabetes requiring daily doses of more than 20 units of fast-acting insulin. https://pdf.hres.ca/dpd_pm/00063278.PDF PM date: April 12, 2021 Source product: HUMALOG MIX 25 (CARTRIDGE); DIN 02240294; fetched 2026-09-10 Product monograph posted by Health Canada; excerpt for lookup only.